Well this is the same question I was going to post here on the forum. Started Orgovyx and Zytiga with prednisone Feb of 26 with a PSA of 55 and T of 413. 4 months later (June 26) PSA 0.28 and T of 1. Convinced the MO to start me on Nubeqa June 17 which I did, slowly weaning my self from the prednisone (from 5mg daily to 2.5 then 2.5 every other day). Now Im thinking: Why take Orgovyx if the Nubeqa mechanism is to inhibit the cancer cells from using testoserone? Can I have my cake and eat it too? Lol. I will have new numbers July 15 and will be reading and researching the trials mentioned here in this post and elsewhere untill then. Probably wait for August numbers then decide what to do.....Take Orgovyx every other day? Then wait for September numbers? Quit taking Orgovyx altogether and see what the September numbers reveal? The side effects of ADT has certainly raised its ugly head: hot flashes every hour, insomnia. I have lost about 10 pounds (now at 190, 6 feet tall) muscle loss I am sure. I exercise and work physically from dawn to dusk but am losing ground in the fight to stay fit and strong. Sex is not an issue, I left that behind several years ago. I just want to keep my bones dense, my body strong and be mentally fit for a guy with GS 8, multiple mets with osteopenia.
What do you think? Start my own little monotherapy trial in 2 months? See where the numbers take me? What do I have to lose except perhaps starting Pluvicto a couple months early? The Dr said Pluvicto was in my future, maybe in a year or two, I guess when the Orgovyx and Nubeqa quit working. I sure would like to feel good for those 2 years, Orgovyx free. As always, thoughts and opinions are most welcome. Thanks for reading my post, I will be reading yours!