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Nubeqa Monotherapy vs Dual Therapy with ADT

Prostate Cancer | Last Active: Jun 30 2:37pm | Replies (18)

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Profile picture for Jeff Marchi @jeffmarc

I know a lot of people over at ancan.org That are on Darolutamide Alone and it works great for them.

You would be better off with Orgovyx To get that testosterone down, Darolutamide Does prevent testosterone from working with the cancer to make it grow, but if you have really high testosterone for a long time, it could be a problem and defeat the drug. It could also defeat Apalutamide Quicker than if you were on ADT as well.

After 7 years of ADT, I stopped Orgovyx And just stayed on Darolutamide for eight months. My Testosterone started rising too fast so my oncologist wanted me to go back on Orgovyx. My PSA stayed undetectable.

I know some people with some very serious prostate cancer cases, who are just on Darolutamide, And it’s been keeping them undetectable. The nice thing about it is that it has no side effects for most people. Apalutamide On the other hand does have side effects and can cause brain fog.

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Replies to "I know a lot of people over at ancan.org That are on Darolutamide Alone and it..."

@jeffmarc wrote " The nice thing about [Darolutamide] is that it has no side effects for most people. Apalutamide on the other hand does have side effects and can cause brain fog."

I think you mean specifically cognitive side-effects. Darolutamide has many general side-effects (as is the case for all ARSIs):
https://www.mayoclinic.org/drugs-supplements/darolutamide-oral-route/description/drg-20470011
The instance of cognitive side-effects seems to be in the low single digits for Apalutamide, percentage-wise, but if you're one of the unlucky ones, switching to Darolutamide is an option.