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DADS-M Neuropathy with Anti-Mag Antibodies...anybody else?

Posted by savomic @savomic, Nov 28, 2022

After 4 years of lower limbs weakness, I was recently diagnosed with Distal Acquired Demyelinating Symmetric with the M protein and tested positive for Anti-Mag Antibodies. Pin and needles in feet and lower limbs, ataxia, weak ankles, and tremor up to my hips. Difficulty walking and balance issues. Originally treated with IVIG with no results. Started Rituximab treatment every 3 months. Anybody else with similar issues?

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John, Volunteer Mentor | @johnbishop | 5 days ago
In reply to @es52 "@johnbishop Hello, I am 73 yr old female dx with CiDP 2 yrs ago and Sjögren’s..." + (show)
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@johnbishop
Hello, I am 73 yr old female dx with CiDP 2 yrs ago and Sjögren’s syndrome more recently. Tried IVIG then Vygart Hytrulo with no improvement. Also have MGUS .
Haven’t been dx with DADS but to try Rituxan in a couple of wks.
My main symptoms are progressive lower leg weakness with bilateral foot drop, very unstable gait, fine tremors in hands and general shaky feeling inside. Unable to balance at all without holding on to cane or walker at this point.
I don’t have much pain but tingling, achy feeling and mainly hand joint stiffness and soreness.
I’m currently on methotrexate, hydroxychloroqine, and duloxetin.
I am really praying the Rituxan will at least give me back some stability. I was perfectly healthy at age 70 other than some low back degenerative symptoms which my dr and I both thought was the problem when symptoms started in my feet.
I did have multiple Covid vaccinations and a mild Covid infection during the pandemic but I don’t think they know why these crazy autoimmune diseases happen.
.

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Hello @es52, Welcome to Connect. Thanks for sharing your treatment experiences. Hoping the Rituxan provides some improvement. I don't have any pain with my idiopathic neuropathy either but do have balance and I'm sure my gait is not very good. I think some of my issues could be related to my degenerative disc disease along with a few other conditions but I'm not sure.

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