@overage
I’m sorry about that. I thought that particular video specifically mentioned radiation was not successful with cribriform.

Unfortunately, I could not find the information. I attend so many of these presentations and I thought that was the one where it was mentioned. It must’ve been another one, but I can’t find it right now.

Here’s some more information which appears that what I’ve heard was dated or doctors differ on their opinions. It’s interesting that this particular forum is mentioned as one of the sites discussing it.

Cribriform morphology (in prostate cancer) is highly aggressive, with a higher risk of metastasis. While some past discussions suggested surgery was better due to early concerns about radiation missing this pattern, recent clinical analyses show radiation combined with hormone therapy is highly effective, significantly reducing the risk of metastasis

.The debate regarding whether surgery or radiation is best for cribriform prostate cancer involves several nuances:

Traditional Perspective: Historically, because cribriform cells are highly aggressive, experts debated whether radiation could completely eliminate them. In many of these cases, surgeons and oncologists favored radical prostatectomy for physical removal.

Modern Radiation Evidence: Recent studies on the management of cribriform-positive cancer indicate that modern radiotherapy—especially when combined with neoadjuvant Androgen Deprivation Therapy (ADT)—is highly impactful, reducing the long-term risk of metastasis by 65%.

Mixed Patient Opinions: On forums like Mayo Clinic Connect and Reddit, opinions on surgery vs. radiation differ, as some patients with cribriform morphology are advised to use combination radiation and ADT while others are guided toward surgical removal.