@mangolinda8191 My spouse has taken it for 15 months so far. He takes it after his dinner meal, even though the exact time of dinner can vary. It's less like an antibiotic where the spacing needs to be more exact and more long-term, in my opinion, but don't ask your oncology team. Whether it gets easier? Not really, but it's been incredibly effective against his cancer. He went from a PET that showed metastatic disease in many locations to a PET six months later that showed no evidence of disease. His biggest side effects are edema (gets worse over time, so try to stay on top of it) fatigue, and sometimes nausea. Sending all my best your way. There is an active MET skipping 14 Facebook group, if that's your type of cancer. And MET crusaders online.