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better than PSA testing !?

Prostate Cancer | Last Active: Jun 28 11:54am | Replies (10)

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Looks like another PSE type test using blood biomarkers, PSA, etc. The UK NICE (part of NHS) writeup is almost 4 years old. It lists a 350 pound price for the test. The other reference one may be from the biotech that is trying to market the test. Text below is from that site.

Stockholm3 is a blood-based test that integrates protein biomarkers, genetic risk profiling, and clinical data to assess a man’s risk of harboring aggressive prostate cancer. Stockholm3 has been evaluated in prospective and population-based screening studies with a total of more than 90,000 men. In a European screening cohort (N=12,670), Stockholm3 has showed 90% sensitivity and 89% specificity for detecting aggressive prostate cancer (Grade Group ≥2 cancer). PSA ≥3 ng/ml showed 74% sensitivity and 90% specificity, while PSA ≥4 ng/ml showed 52% sensitivity and 95% specificity in the same cohort.[15, 16] Stockholm3 has been shown to enable detection of aggressive cancers while reducing unnecessary biopsies in men with elevated PSA levels compared to PSA-based referral pathways.[15-18] Long-term follow-up from the population-based European STHLM3 screening study suggests that cancers identified at low PSA levels but elevated Stockholm3 scores may be biologically aggressive and clinically meaningful. Men diagnosed under these conditions had an approximately ninefold higher risk of high-risk biochemical recurrence (an indicator of progression to metastatic and potentially lethal disease) after curative treatment compared with men with higher PSA but low Stockholm3 risk (HR 8.8; 95% CI: 1.06–72).[14]
https://www.stockholm3.com/usa
The UK reference from 2022 about this test:
https://www.nice.org.uk/advice/mib303/resources/stockholm3-for-prostate-cancer-screening-pdf-2285967566184901

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Replies to "Looks like another PSE type test using blood biomarkers, PSA, etc. The UK NICE (part of..."

@jim18 Ah, thanks. The Fox News article linked from the one in the OP didn't mention a blood component. My bad for trusting a somewhat iffy news source without independent confirmation.

So the real story is that PSA is a bit of a blunt instrument (as we already know), and before doing an invasive biopsy, we should do a second string of non-invasive epigenetic testing first.

Note that a very high PSA (e.g. 50 or 500) is almost guaranteed to be caused by prostate cancer. It's only when you have a slightly-elevated PSA like, say, 10, when it's sort of a coin toss whether there's cancer involvement or not. That would be the situation that these epigenetic secondary screening tests are addressing, and they could prevent some unnecessary biopsies.

@jim18
The first link to http://www.stockholm3.com/usa doesn’t work.

It says they couldn’t find the page we were looking for.

It also doesn’t show that it’s available in the USA.

Stockholm3 is currently available in the following markets: The UK, Switzerland, Germany and the Nordic countries. For information on how to order the test, please contact:

Europe

Germany: Labor Dr. Wisplinghoff, e-mail: labor@wisplinghoff.de; telephone: +49 (0) 221 940 5050

Switzerland: labor team, e-mail: info@team-w.ch; telephone: +41 71 844 45 45

UK: The Doctors Laboratory, e-mail: stockholm3@tdlpathology.comTelephone +44(0) 207 307 7373

Nordics (Sweden, Norway, Finland): A3P Lab Customer Service, Uppsala, Sweden. E-mail: customersupport@a3p.com, telephone: +46 (0) 10-182 33 01

All other markets

A3P Lab customer service, Uppsala, Sweden.
E-mail: customersupport@a3p.com, telephone: +46 (0) 10-182 33 01

Andreas Hoel - VP Marketing and Sales.
E-mail: andreas.hoel@a3p.com, telephone: +45 2597 4250