@ndmcl49 Welcome to Mayo Clinic Connect. Your question stood out to me as I experienced something similar although the conditions were different but resulted in same physiologic response that can occur with underlying autoimmune conditions. In my case, mine was heightened by immunotherapy which led to immune checkpoint inhibitor colotis which in turn led to enteropathic arthritis, or pseudogout - in short, a huge inflammatory response resulting in 60cc of fluid accumulating in one knee alone. In fact, I learned about my own RTC (rotator cuff tear) when I had a flare over the winter that caused shoulder pain.

So, short answer: YES. This is largely due to the release of cytokines, chemical messengers of sorts in the immune system that can become activated with inflammation, infection or injury within the body. Another protein in the body also rises during such times, CRP or C-reactive protein. In cases of skin disorders, this can result in increased irritation, dryness, redness, and itching. In my case, it affected something known as the gut-joiint axis. It's really amaizing to see how interconnected the body is and how it can react - but sure is debillitating to suffer through these consequences, isn't it? Are you feeling some relief now, and how is your RTC being treated?