My husband was in pretty rough shape after his 6 months of folfirinox. I think they had him on a reduced dosage after the 6 months and he was able to return to doing more normal activities in those first couple months. Unfortunately taking a break from the chemo allowed to cancer to take over again. The doctor said trying gem/abrax would be next and unfortunately that did not work for him. He was ready to try an experimental drug that his doctor was able to obtain, but died before he had the chance to try it. Yes, as others mentioned, fatigue and neuropathy were severe, and nausea for a few days after each treatment. But except for the neuropathy those symptoms ended fairly quickly when he went on a lower reduced dosage.