Has anyone found a treatment that helps with peripheral neuropathy?

Posted by bigjohnscho @bigjohnscho, Jul 1, 2025

I suspect that everyone on this forum has been searching for a medication that helps their neuropathy and even though you no that all the internet claims are false we continue to waste hundreds of pounds. Desperation is a powerful force. Has any one been fortunate enough to find a genuine treatment. I just can’t believe that there are so many awful people who prey on our vulnerability and knowingly orchestrate such elaborate scams.

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Profile picture for arnhilda @arnhilda

@sam3120
I have burning sensation in my body and tingling on both feet. I put Vicks Vaporub on my feet and it helps

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@arnhilda -- I've been applying Vicks Vaporub since for last 5 months ... helps somewhat. -Minutes ago, I learn there is the "Kampo"
Japanese herbal approach--- more to learn.

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I am a patient, not a Dr. I understand, no cure for PN. However story doesn't end there. CET treatments exist to reduce the pain. CET may not cure the underlying cause of PN, but CET treatment helped me to generate some new nerve growth which helps in reducing some of the pain while enabling mobility. I walk and drive better. I am doing much much better which improves my life now. Only time, my diet, and exercise will determine blood sugar levels and if/when it gets worse again. Maybe in the future a underlying cure will be found. Until then treatment that helps to reverse or slow nerve damage to any extent is good for me. Medicare covered my CET treatment. I see it as a way to see relief, better then just masking pain.

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What has worked for me is the red near infrared light mat helicopter and I rub frankincense balm on my feet and legs at night and morning. I don’t take the drugs to many side effects and didn’t really help just caused more problems. I only try things that you can return for a full refund if it doesn’t work or insurance covers it. You are absolutely right about people praying on you when you’re trying to find something that gives you relief from PN. I can sleep thru the night with out being woke in pain. I’m also trying the vibrating plate now just got it yesterday.

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Profile picture for dennisntexas @dennisntexas

I am a patient, not a Dr. I understand, no cure for PN. However story doesn't end there. CET treatments exist to reduce the pain. CET may not cure the underlying cause of PN, but CET treatment helped me to generate some new nerve growth which helps in reducing some of the pain while enabling mobility. I walk and drive better. I am doing much much better which improves my life now. Only time, my diet, and exercise will determine blood sugar levels and if/when it gets worse again. Maybe in the future a underlying cure will be found. Until then treatment that helps to reverse or slow nerve damage to any extent is good for me. Medicare covered my CET treatment. I see it as a way to see relief, better then just masking pain.

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@dennisntexas please advise what is CET treatment This sounds interesting Thanks

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Profile picture for connie1944 @connie1944

@dennisntexas please advise what is CET treatment This sounds interesting Thanks

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@connie1944 Forgot to mention I am not diabetic Neurapathy

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Profile picture for connie1944 @connie1944

@dennisntexas please advise what is CET treatment This sounds interesting Thanks

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@connie1944 - Combined Electrochemical Therapy (CET) - @dennisntexas started a discussion on the treatment here - https://connect.mayoclinic.org/discussion/has-anyone-benefitted-from-cet-neuropathy-treatment/.

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Profile picture for jayol @jayol

@gnocchi
I also have taken Gabapentin and had bad side effects. Would you share what dosages you take of the supplements.

Thank you

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@jayol I tried capzaisin and it really helped. I also got compression socks, yes they help a lot wearing them all day. I hope this helps.

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I've tried all the meds and been to several doctors and nothing helped, but I discovered two things that do help reduce the pain for me. I stay very well-hydrated by drinking lots of water throughout the day and overnight. Plus, I keep my feet WARM AT ALL TIMES by wearing insulated hiking boots or insulated snow sneakers during the day year round plus, I wear insulated slippers to bed and place several layers of blankets on the bed from the mid-thighs down. I never let my feet get chilled for even a few minutes. If my feet get cold, my neuropathy flares up and I can suffer with severe pain for a day or two, or even three. Now, drinking water and always keeping my feet warm will prevent much of the pain but it won't quickly relieve pain if I let my feet get cold. It might take a day or so for my feet to warm up and the neuropathic pain to subside. Yes, I go to the bathroom more frequently but it's a small price to pay to get sustantial pain relief. No neurologist or other MD ever mentioned this. I came upon it on my own after years of suffering. Maybe this method will work for you. Also, stay away from caffeine!! It is a vasoconstrictor that will freeze your feet in short order!!

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Profile picture for dennist0721 @dennist0721

@mikead63 One possible future treatment I have been following. I think it may be in clinical trials now. Yes, the Fibroblast Growth Factor 1 (FGF1) protein shows strong promise in preclinical models for treating neuropathy and neuropathic pain. However, it remains highly experimental and is not yet an approved treatment for human patients. [1, 2, 3, 4]
Here is how FGF1 shows potential and where the research stands:
How FGF1 Targets Neuropathy

• Nerve Regeneration: FGF1 stimulates the proliferation and migration of Schwann cells (the cells that insulate and support nerves), which helps repair damaged myelin and regenerate nerve fibers.
• Pain Reduction: Preclinical studies indicate that FGF1 can reverse mechanical and thermal hypersensitivity—key symptoms of neuropathic pain—by reducing neuroinflammation in the spinal cord.
• Diabetic Neuropathy: In diabetic models, FGF1 has been shown to counteract oxidative stress and inflammation, actively protecting nerves from high blood-sugar damage. [3, 11]

Current Limitations and Risks

• Human Data is Limited: The most promising results for FGF1 come from animal studies. Clinical trials in humans are scarce, and it is not yet an FDA-approved therapy for neuropathy.
• Delivery and Side Effects: Growth factors like FGF1 are difficult to deliver safely across the nervous system, and there are theoretical risks that stimulating cell growth could lead to abnormal cell division or tumor formation. [1, 4]

Currently, standard neuropathy treatments primarily focus on symptom management and blood-sugar control rather than direct nerve regeneration. [12, 13, 14, 15, 16]
If you are managing a specific type of neuropathy (such as diabetic peripheral neuropathy), tell me:What are your primary symptoms (e.g., pain, numbness, tingling)?Are you currently taking any medications for pain relief?I can provide more tailored information regarding available options.
AI responses may include mistakes.

[1] https://www.youtube.com/watch
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC8019860/
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC7819983/
[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC12985528/
[5] https://blueridgeintegrativehealth.com/blog/enhancing-neuropathy-treatment-with-nitric-oxide-our-comprehensive-approach
[6] https://medresearch.umich.edu/research-news/stephanie-eid-phd-earns-important-grant
[7] https://pubmed.ncbi.nlm.nih.gov/25589163/
[8] https://pubmed.ncbi.nlm.nih.gov/28949091/
[9] https://www.sciencedirect.com/science/article/abs/pii/S0006899325001738
[10] https://pmc.ncbi.nlm.nih.gov/articles/PMC5974208/
[11] https://pmc.ncbi.nlm.nih.gov/articles/PMC12010074/
[12] https://www.nhs.uk/conditions/peripheral-neuropathy/treatment/
[13] https://www.cdc.gov/diabetes/diabetes-complications/diabetes-and-nerve-damage.html
[14] https://www.mayoclinic.org/diseases-conditions/diabetic-neuropathy/diagnosis-treatment/drc-20371587
[15] https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00929/full
[16] https://arpwave.com/understanding-neuropathy-and-how-arpwave-can-help/

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@andries240644
Have idiopathic peripheral neuropathy but really manifests in only right lower leg calve muscle weakness and drop foot. Previously had a drop foot problem which was dealt with a lower spinal cord operation. That was 10 years ago. A recent mri according to specialist shows no nerve compression. Sent me to a neurologist who diagnosed neuropathy. I suppose that he is correct but the drop foot return to my mind also points to something in addition.

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There is no one answer because people’s neuropathies and ridiculous path. These happen for different reasons. So what works for one person doesn’t work for another. It depends on your age whether your digestive track is working optimally and if you have any impinge discs in your spine.
The neuropathy I developed the last few years was resolved when I started taking HEME iron pills along with my B12 vitamin supplements. I also do light exercise along with that. When we get older, we don’t digest things as well and our nerve sheaths scream at us in reaction. It could be different supplements for different people. My doctor didn’t fix this. The only thing they would offer are steroid injections because my spine is really screwed up. But I ended up being anemic which happens to me periodically and I tried a different iron pill, and that was it. My problem was solved. I read up on it more. I already take B12 injections and adding the HEME iron to that solve my problem. And the research behind it explained why.— in my case. I am 69.

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