Effexor tapering question

Posted by trenxt @trenxt, Jul 12, 2025

I was on 112.5mg of XR for chronic pain. I started to taper from it over 20 weeks ago by cutting every 2 weeks. It was changed to IR in liquid form and I split it into 3 doses a day. Problem is I never did the math on how much the psychiatrist was cutting every time. I wasn't having issues at first as soon as I came down to around 60mg I'm getting stomach pain constantly, lost weight because can't eat due to pain, insomnia is horrible 3 4 days no sleep. I'm at 31mg and I can't keep going like this. I did the math and if I ask for an adjustment to cut 10% of the last dose every 2 weeks will take me another year or so to get off this horrendous drug. Is there a way I can ask to be given another medication that can cover effexor so I don't have to take it anymore and taper off that other one then. This is too painful.

Will I face withdrawal if I cross to another antidepressant? Please inform me.

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Profile picture for sallyo420 @sallyo420

@kaelan
In January of this year I went off 225mg Effexor using a Prozac bridge and it was very easy. I had no withdrawal symptoms. I don't know why all doctors don't prescribe it.

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@sallyo420 when did the prozac start working for you? I am day 1 of week 6, i still feel anxious and jittery

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Profile picture for casstate @casstate

@sallyo420 when did the prozac start working for you? I am day 1 of week 6, i still feel anxious and jittery

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@casstate - you might mention this to the healthcare professional who prescribed it. I take fluoxetine (Prozac), and I had to tell my doctor it was helping but not enough yet. She doubled it, and it really helped me feel like myself again.

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Profile picture for casstate @casstate

@sallyo420 when did the prozac start working for you? I am day 1 of week 6, i still feel anxious and jittery

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@casstate When I first started going off of it, I started using 37.5 Effexor and 40 mg of Prozac for each 75mg. I waited a week for the Prozac to take effect and then went off the whole 75mg and added 10mg or 20mg more of Prozac if needed. Then I kept going off another 37.5mg with the prozac and had no side effects at all. I stayed on the Prozac for 2 months to avoid any long term effects from the Effexor. Going off the Prozac was easy with the long half life it has.

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In reply to @bluebird1953 "@depressedbutnotdead" + (show)

@bluebird1953 the above was not my comment. Effexor has saved my life. Tried other meds but always went back to Effexor. I have been on 300 mg for many years. No side effects like other meds. No reason for it to be taken off the market when it helps many. Everyone one has a different reaction to many meds. It’s always trial and error. Difficult but it’s the only way.

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Profile picture for depressedbutnotdead @depressedbutnotdead

I stopped cold turkey about a year-and-a-half ago. I don't advise this, but in my case, after long term use, it began driving me into a very dangerous depression and causing serious behavioral issues and self-harm actions. There are studies showing this is a rare but documented response. I was on it for 20 years, yet somehow managed to ride out the worst of the withdrawal in about four to six weeks. After that I had months of surging emotions, although I was good with this as, looking back, I feel that Effexor shut down a lot of my capacity for feeling the fullness of life, both the joy and the sorrow. I was emotionally flatlined except for extreme rage, which began developing as I tumbled into massive depression and is very uncharacteristic of me.

It became a nightmare drug for me, and even my psychiatrist is in full agreement that the antidepressant was what was fueling my severe and deepening depression. 18 months after quitting, she's all but cut me loose. She's not worried about me harming myself now (I was hospitalized about two years ago).

I've grown deeply critical of how the drug is handled. I was never told about the difficulties of quitting it (I'm an outlier for being able to wean off of it so quickly; I've heard no end of nightmare stories from others). I was never told about the black box warnings that, it turned out, applied to me. It was prescribed by a family physician who just handed it to me and said if it doesn't work, come back. No medical monitoring. No psychological monitoring. No warnings. Nothing. Just take it and hopefully you'll feel better. Frankly, I don't know if a lot of general practitioners are even aware of the potential pitfalls of it.

I have come across this story on forums repeatedly. People are prescribed it, but not told that quitting it could be a brutal and prolonged experience. They only find out when they decide to quit. This should not be happening.

Antidepressants do save lives, but patients need to be making informed decisions. But in my case, as well as that of many I've seen who have recounted their experiences on forums, this simply doesn't happen.

I did switch to a different provider, a much younger P.A. who is fully cognizant of the possible negative side effects of antidepressants. As I was relaying my experience, he told me that he's very cautious with antidepressants, informs patients before prescribing them that if they need to quit, it could be extremely difficult, and if they do decide to try them he has them to come in regularly for a emotional and physical checks. That's how it should be.

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@depressedbutnotdead
I have just kicked( with Great difficulty) Venafaxine after 20 years that I was given for menopause symptoms??tapering down over a very long time . A couple of failures after horrendous psychotic distressing side effects. I have now been off fully for 4 weeks hurrah!! But now am getting terrible night panics waking me up. They don’t tell you these effects I wonder if doctors really understand?or particularly help you get off these drugs.?I was told you will need to take a low dose for life now your body is use to it?? It was menopause ffs ?No! Anyway im off and hope these panics subsided?
.

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Profile picture for cherrycherry @cherrycherry

@depressedbutnotdead
I have just kicked( with Great difficulty) Venafaxine after 20 years that I was given for menopause symptoms??tapering down over a very long time . A couple of failures after horrendous psychotic distressing side effects. I have now been off fully for 4 weeks hurrah!! But now am getting terrible night panics waking me up. They don’t tell you these effects I wonder if doctors really understand?or particularly help you get off these drugs.?I was told you will need to take a low dose for life now your body is use to it?? It was menopause ffs ?No! Anyway im off and hope these panics subsided?
.

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The great problem with the doctors is that they don’t tell you the effects of medicines clearly. I must always ask: how long does it take before this medicine effects, how does it effect with other medicines, how long time does it take before the effect of medicine disappears totally from my body and if you mix them how does it effect to my brains (< important).

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Profile picture for marja27 @marja27

The great problem with the doctors is that they don’t tell you the effects of medicines clearly. I must always ask: how long does it take before this medicine effects, how does it effect with other medicines, how long time does it take before the effect of medicine disappears totally from my body and if you mix them how does it effect to my brains (< important).

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@marja27
You are correct. Most doctors don’t have the lived experience we have . They just go by the medical book. Sometimes they are clueless.

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Hello! Most doctors are well-payed, so they should know.

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