Has anyone found a treatment that helps with peripheral neuropathy?

@granny73
I have idiopathic sensory neuropathy but do NOT take Lyrica or Gabapentin - bad side effects but instead take alpha lipoic acid and medical grade B complex vitamins and S-Acetyl Glutathione. I do not have diabetes but had pins and needles and numbness and burning all over my body - dr had prescribed these two awful medicines and when I tried Lyrica lowest dose it just made me so tired I could hardly walk to my car. Anyway, am a happy camper now and hope it does not come back - drs don't know a thing about supplements. They make money prescribing meds - anyway I found out about Alpha lipoic acid here in these forums so truly tested and my Back to Nature person said Source Naturals was the best
brand. It's been weeks now and am symptom free - I was ready to sit down and die as there is no cure. I pray these supplements continue to work.

Thank you for sharing this. Can I find those vitamins in a drug store over the counter?

I have been using Alpha Lipoic Acid 600 mg and Wes tab one which is a B vitamin and use Mama Bear Oasis cream on my feet when needed for the past several months and I have seen much improvement. From what I read, Neuropathy does not go away, but one can live with it taking supplements that help it be more bearable.

@gnocchi

At a recent doctor's visit, I told him I was able to reduce my daily gabapentin dose from 2400 mg (600 x4) to 1200 mg (300x4) after I started taking R alpha lipoic acid 900mg a day (300x3).
He looked at me kinda funny. Then as I was sitting there, he googled R alpha lipoic acid and apparently was satisfied it was legit.

By the way, I tried pronouncing the word gnocchi for two Italians. They both said, I never got it right!

I have idiopathic neuropathy in both my feet, no diabetes. I've had this for about 7 years & it's gotten progressively worse. I also don't take any meds for it. I found this Mayo Clinic post for the first time last week searching for some relief for nights - the burning & tingling keeps me up. It's exhausting. Someone here suggested lidocaine. I have been putting lidocaine pads (Salon Pas) on the bottom my feet (I 've tried everything & figured I had nothing to lose). It may be unique to me but I can't believe the relief I'm getting! These pads quell my pain and I can finally sleep through the night. Sharing this info as it may be helpful to someone else.

@gnocchi
I also have taken Gabapentin and had bad side effects. Would you share what dosages you take of the supplements.

Thank you

@sam3120
I have burning sensation in my body and tingling on both feet. I put Vicks Vaporub on my feet and it helps

Look into CET treatment. You can Google it or allow AI to find it and tell you all about it. Not a perfect fit but on day 71 of treatment I am much much better.

I don't know if red light therapy works but a friend of mine claims it helped him. His mom used it for another problem and said it didn't help her.
I'm not sure whether her son just thought it helped or if it actually did help, but even if it was psychological it still worth it. Someone here on connect once paid $8000 for some type of device and claimed at work and I asked my doctors about it. Both of them said that it couldn't have worked so who knows maybe it was psychological, but it was still worth the $8000 if it got rid of her pain or even if she only thought it got rid of it according to my doctors.
Take care,
Jake

@mikead63 One possible future treatment I have been following. I think it may be in clinical trials now. Yes, the Fibroblast Growth Factor 1 (FGF1) protein shows strong promise in preclinical models for treating neuropathy and neuropathic pain. However, it remains highly experimental and is not yet an approved treatment for human patients. [1, 2, 3, 4]
Here is how FGF1 shows potential and where the research stands:
How FGF1 Targets Neuropathy

• Nerve Regeneration: FGF1 stimulates the proliferation and migration of Schwann cells (the cells that insulate and support nerves), which helps repair damaged myelin and regenerate nerve fibers.
• Pain Reduction: Preclinical studies indicate that FGF1 can reverse mechanical and thermal hypersensitivity—key symptoms of neuropathic pain—by reducing neuroinflammation in the spinal cord.
• Diabetic Neuropathy: In diabetic models, FGF1 has been shown to counteract oxidative stress and inflammation, actively protecting nerves from high blood-sugar damage. [3, 11]

Current Limitations and Risks

• Human Data is Limited: The most promising results for FGF1 come from animal studies. Clinical trials in humans are scarce, and it is not yet an FDA-approved therapy for neuropathy.
• Delivery and Side Effects: Growth factors like FGF1 are difficult to deliver safely across the nervous system, and there are theoretical risks that stimulating cell growth could lead to abnormal cell division or tumor formation. [1, 4]

Currently, standard neuropathy treatments primarily focus on symptom management and blood-sugar control rather than direct nerve regeneration. [12, 13, 14, 15, 16]
If you are managing a specific type of neuropathy (such as diabetic peripheral neuropathy), tell me:What are your primary symptoms (e.g., pain, numbness, tingling)?Are you currently taking any medications for pain relief?I can provide more tailored information regarding available options.
AI responses may include mistakes.

[1] https://www.youtube.com/watch
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC8019860/
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC7819983/
[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC12985528/
[5] https://blueridgeintegrativehealth.com/blog/enhancing-neuropathy-treatment-with-nitric-oxide-our-comprehensive-approach
[6] https://medresearch.umich.edu/research-news/stephanie-eid-phd-earns-important-grant
[7] https://pubmed.ncbi.nlm.nih.gov/25589163/
[8] https://pubmed.ncbi.nlm.nih.gov/28949091/
[9] https://www.sciencedirect.com/science/article/abs/pii/S0006899325001738
[10] https://pmc.ncbi.nlm.nih.gov/articles/PMC5974208/
[11] https://pmc.ncbi.nlm.nih.gov/articles/PMC12010074/
[12] https://www.nhs.uk/conditions/peripheral-neuropathy/treatment/
[13] https://www.cdc.gov/diabetes/diabetes-complications/diabetes-and-nerve-damage.html
[14] https://www.mayoclinic.org/diseases-conditions/diabetic-neuropathy/diagnosis-treatment/drc-20371587
[15] https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2019.00929/full
[16] https://arpwave.com/understanding-neuropathy-and-how-arpwave-can-help/