@loribmt hello. I am a CLL patient monitored quarterly since 2023. I started Calquence mid 2026 my body tolerated the Calquence for 33 days starting unbearable burning pain in fret valves and hands forcing stopping the Calquence. 2 weeks later I started Zanubrutinib and 3 days of Zanubrutinib the unbearable burning pain in calves feet & hands I stopped the Zanubrutinib. This week the doctor recommended infusion and pill therapy and I’m skeptical of therapies because the immediate debilitating painful reaction my body had to the first 2 therapies. Should I get a second opinion from another doctor.