The Role of Repurposed Drugs in Prostate Cancer Therapy

Posted by doyourresearch @doyourresearch, 1 day ago

I would like to hear others' opinions regarding the use of repurposed drugs for the treatment of prostate cancer. What do you know about them? Have any of your care professionals recommended any, and, if so, what has been your experience?

We hear a lot about prostatectomies, radiation, chemotherapy, ADT, etc., but not about existing low-cost, generic medications, some of which seem to have some pretty solid evidence behind them.

Please weigh in with your thoughts for the benefit of this group. Thank you.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

There are no drugs you can take, that are not the ones recommended by doctors for prostate cancer, that work. Not sure what you’re looking at, but there is a lot of bogus information out there. The guy that used to write the Dilbert comics tried alternate drugs before he decided to actually go on to the real thing. He is dead. Delaying real treatment can result in a very short overall survival.

Here’s one of the bogus treatments

Ivermectin Benzimidazole Prescribing Following Celebrity Endorsement
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2848862
There’s a couple of more articles about misinformation people are getting about prostate cancer
https://anticancerlifestyle.org/cancer-misinformation-is-more-common-than-we-think/
https://ufhealth.org/news/2025/study-finds-most-cancer-patients-exposed-to-misinformation-uf-researchers-pilot-information-prescription

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Profile picture for Jeff Marchi @jeffmarc

There are no drugs you can take, that are not the ones recommended by doctors for prostate cancer, that work. Not sure what you’re looking at, but there is a lot of bogus information out there. The guy that used to write the Dilbert comics tried alternate drugs before he decided to actually go on to the real thing. He is dead. Delaying real treatment can result in a very short overall survival.

Here’s one of the bogus treatments

Ivermectin Benzimidazole Prescribing Following Celebrity Endorsement
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2848862
There’s a couple of more articles about misinformation people are getting about prostate cancer
https://anticancerlifestyle.org/cancer-misinformation-is-more-common-than-we-think/
https://ufhealth.org/news/2025/study-finds-most-cancer-patients-exposed-to-misinformation-uf-researchers-pilot-information-prescription

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@jeffmarc Thank you for your input Jeff.

There are repurposed drugs that are recommended by some doctors as part of some treatment protocols for prostate cancer. Please note the terms "some doctors" and "some treatment protocols". I never stated, nor meant to imply, that repurposed drugs were the entire treatment protocol.

Also, please note I stated recommended by "care professionals" in my original post, not celebrity endorsers, nor internet influencers, nor quacks.

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Profile picture for doyourresearch @doyourresearch

@jeffmarc Thank you for your input Jeff.

There are repurposed drugs that are recommended by some doctors as part of some treatment protocols for prostate cancer. Please note the terms "some doctors" and "some treatment protocols". I never stated, nor meant to imply, that repurposed drugs were the entire treatment protocol.

Also, please note I stated recommended by "care professionals" in my original post, not celebrity endorsers, nor internet influencers, nor quacks.

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@doyourresearch
Hello...I find all information interesting...perhaps if you were to be more specific? What repurposed drugs are recommended by doctors? What doctors? And what treatment protocols for prostate cancer?
The "care professionals" covers a wide range of people, with varying degrees of expertise.
Most folks here are data driven (my opinion) as am I. As a stage 4 multiple node metastatic person I am open to new ideas. I tried one of the "repurposed drugs for several months, when I was first diagnosed, with no postive results (PSA stayed the same, 55) before going on ADT. I dont like it but it works. I have been a reader of the "evidence.zone" Good info there. Several people here believe white button and turkey tail mushrooms work for them. Another here was sticking with the Rick Simpson Oil program. My neighbors brother is on a ivermectin/fenben program, his PSA is 118 and continues to rise...he says he is taking it day by day. Hope is a wonderful attribute but not a strategy. We are as prostate cancer patients (I believe) are: overmedicated, overtreated, pushed into surgery and radiation before educating ourselves about the disease. My MO told me: prostate cancer is a business. I told him: I realize that every cancer patient represents tens of thousands of dollars to the medical business model. Lol. We get along pretty good but I am in charge of my treatment. Thank you for reading my response to your post, I have been reading your posts, I would like to read the book by the Dr you recommended but it costs 40 dollars, Id rather spend my money supplements (I take a handful)! Dont we all. Lets talk!

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Profile picture for doyourresearch @doyourresearch

@jeffmarc Thank you for your input Jeff.

There are repurposed drugs that are recommended by some doctors as part of some treatment protocols for prostate cancer. Please note the terms "some doctors" and "some treatment protocols". I never stated, nor meant to imply, that repurposed drugs were the entire treatment protocol.

Also, please note I stated recommended by "care professionals" in my original post, not celebrity endorsers, nor internet influencers, nor quacks.

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@doyourresearch
If there were any drugs out there that worked with prostate cancer, other doctors would be using them Not some doctors that were repurposing drugs.

If there was another drug that really helped, it would be news to all of us. How about giving us some names of some drugs that are supposed to help?. If it’s Keytruda you need to look into what really goes on with that drug and how it only works with certain specific issues that can arise with MSI. If you think it’s a PARP inhibitor, you need to look into the actual test that shows that it really doesn’t work with anything but BRCA2.

There are no repurposed drugs that actually do anything. If there were, they would be standard usage drugs.

Of course, if you could get into a clinical trial or get access to one of those drugs, you might say oh it’s been repurposed.

So give us some names.

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Profile picture for Jeff Marchi @jeffmarc

@doyourresearch
If there were any drugs out there that worked with prostate cancer, other doctors would be using them Not some doctors that were repurposing drugs.

If there was another drug that really helped, it would be news to all of us. How about giving us some names of some drugs that are supposed to help?. If it’s Keytruda you need to look into what really goes on with that drug and how it only works with certain specific issues that can arise with MSI. If you think it’s a PARP inhibitor, you need to look into the actual test that shows that it really doesn’t work with anything but BRCA2.

There are no repurposed drugs that actually do anything. If there were, they would be standard usage drugs.

Of course, if you could get into a clinical trial or get access to one of those drugs, you might say oh it’s been repurposed.

So give us some names.

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@jeffmarc You are entitled to your opinion Jeff, and I respect that. I am not here to get into a debate, but to obtain others' opinions based on their unique, individual experiences. Thank you for sharing yours.

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Profile picture for Jeff Marchi @jeffmarc

@doyourresearch
If there were any drugs out there that worked with prostate cancer, other doctors would be using them Not some doctors that were repurposing drugs.

If there was another drug that really helped, it would be news to all of us. How about giving us some names of some drugs that are supposed to help?. If it’s Keytruda you need to look into what really goes on with that drug and how it only works with certain specific issues that can arise with MSI. If you think it’s a PARP inhibitor, you need to look into the actual test that shows that it really doesn’t work with anything but BRCA2.

There are no repurposed drugs that actually do anything. If there were, they would be standard usage drugs.

Of course, if you could get into a clinical trial or get access to one of those drugs, you might say oh it’s been repurposed.

So give us some names.

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@jeffmarc

I might be wrong - but wouldn't estrogen be considered as "repurposed" drug for PC treatment ? Just a thought 🤔

I read not long ago that there are other cancers where with the help of AI some meds were repurposed with good results. I guess we never know what might help and I truly believe that AI will be great help in finding new drugs or finding old ones that might work for different diseases in general.

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Profile picture for surftohealth88 @surftohealth88

@jeffmarc

I might be wrong - but wouldn't estrogen be considered as "repurposed" drug for PC treatment ? Just a thought 🤔

I read not long ago that there are other cancers where with the help of AI some meds were repurposed with good results. I guess we never know what might help and I truly believe that AI will be great help in finding new drugs or finding old ones that might work for different diseases in general.

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@surftohealth88
Yes! I believe (and hope) that AI will change the cancer landscape as we know it soon.
It already can compare millions of biopsies in seconds. Next will be petscans, mri, etc.
This is an interesting post to have a conversation about!

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Yes, lets all play nice!

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Profile picture for surftohealth88 @surftohealth88

@jeffmarc

I might be wrong - but wouldn't estrogen be considered as "repurposed" drug for PC treatment ? Just a thought 🤔

I read not long ago that there are other cancers where with the help of AI some meds were repurposed with good results. I guess we never know what might help and I truly believe that AI will be great help in finding new drugs or finding old ones that might work for different diseases in general.

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@surftohealth88
After a clinical trial showed it to be equal to ADT, And the report is out and released, It’s just another drug in the Collection of choices doctors have.

I would consider a repurpose drug to be some other drug that has never been in a clinical trial for prostate cancer being used to see if it works.

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