https://www.sciencedirect.com/science/article/pii/S2667089526000015
The body naturally calcifies plaque wherever it is deposited and, if you take a statin, it goes faster (statins work by calcifying and 'cementing' plaque so that it doesn't get dislodged and move downstream where it can cause strokes).

Risk rises with increased scores, although I don't believe it is necessarily linear. And, for the major blood vessels, carotid and LAD, for example, the occlusion has to reach +/-70% before they will discuss bypasses and other remedial action. Even then, if you're asymptomatic, they tend to want to 'let 'er ride.'

As you must know already, each body is different, even those genetically related. My dad was having poor vision and losing ground cognitively...the latter quite apparent to his children. He was 87 at the time. He needed a hip replacement, but in the mandatory workups it was found that his right carotid was fully occluded and his left was 90%. The surgeon wouldn't touch him. Surgery (endarterectomy) followed, and he ended up with the hip replaced, and lived until six weeks short of 96. On my dad's advice, I requested a Doppler ultrasound from my PCP, who granted it. The results were very good.

I have never had a CAC score, at least not relayed to me in those terms. I had an angiogram, two MIBI stress tests on treadmill with contrast, echos.....and none of them showed ischemia, which my cardiologist felt was causing my arrhythmia, atrial fibrillation. It wasn't. It was severe sleep apnea. That, at least, was something my dad and I shared health-wise. 🙂