@alley1 You will need to increase the dose to lose weight. It is just a matter of how fast you go to allow your body to adjust. Your second pen should also be a combo. It can be used for another 2 doses at .25 and then you can finish out the .5 doses left in the first pen; then finish up the second pen (total of 6 .25 and 5 .50). In the fridge pen is good (per Nova) for 8 weeks from first use. The first pen expires right after your 9th shot; second pen after 13th shot so can be used to get 11 shots between 2 pens and still be within Novo guidelines. If you feel good about stepping up now you will get six .50 doses from the two pens for a total of 10. At that point you will need to decide if you are ready to step up to 1.0mg or need another intro pen. For best weight loss will probably need to go to 1.0mg at some point. It is not a race. More side effects are suffered by those that race through titration.