@tallperson Yes, you are supposed to take them with food, as with most vitamins, I believe, as they may need fat to be absorbed. When I was put on Metformin, my GP said to take it with even a few crackers in the morning, as I don't eat breakfast, as many people react badly to taking medication on an empty stomach. I'm lucky, I guess, as I'm fine taking any kind of medication so far, including Areds2. I don't know if Areds help in the long run, but it's worth persevering with if there's any chance at all. Good luck.