← Return to Forteo (teriparatide) followed by HRT: My Experience

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@singingbones
I want to point out that there are no clinical trials studying HRT as the sole follow-up antiresorptive after any anabolic (Forteo/teriparatide, Tymlos/abaloparatide, or Evenity/romosozumab). That doesn't mean it can't work - it just means we're in uncharted territory and need to monitor closely so we don’t lose the precious gains.

The bone density (BMD) gained with Evenity tends to be lost at a faster rate after stopping compared to the gains from Forteo or Tymlos, if no antiresorptive follows, according to observational studies. This is because Evenity suppresses bone breakdown during treatment, and when it's stopped, bone breakdown (CTX) rebounds, sometimes even higher than it was before treatment started. Forteo and Tymlos don't cause this kind of rebound. This makes the choice and adequacy of the follow-up treatment after Evenity especially important.

Have you checked how your dose of estrogen gel compares to the doses typically associated with bone benefits? The most-studied dose for fracture prevention is equivalent to about a 50 mcg estradiol patch (or oral estradiol 1–2 mg). Lower doses could still help, but the evidence is strongest at standard doses. It may be worth discussing with your doctor whether a dose titration plan makes sense - or having a backup antiresorptive plan ready. I had one year worth of prescriptions written in advance to step up from 25 to 37.5 to 50 mcg patches if my bone markers or DXA suggest lower dose isn't enough.

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Replies to "@singingbones I want to point out that there are no clinical trials studying HRT as the..."

@mayblin - thanks for the additional Evenity info. Yes, many of us are in uncharted territory. These forums are so helpful in sifting/sorting our OP journeys when the studies are just not available at this time.

Yes, I am aware of optimal levels of estradiol to impact bone integrity. I've only had one appt w/my new dr & she will be evaluating at our next appt. It's so refreshing to have finally found someone who actually is familiar w/the correlation to bone strength--my previous ones were still basing doses on symptoms.

How wonderful that your Dr provided those prescriptions in advance - saves both of you time/money. I might mention that to my Dr at the next appt. Your dose strength examples are helpful to me as I navigate this journey.

@mayblin, Are you now taking a higher estrogen patch than 25 mcg? Or has that been enough to hold in gains. I am on only 25 mcg hoping it will keep my Forteo/Tymlos gains. It has only been 3 months since I stopped Tymlos.