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Optimal Duration of Hormone Therapy
Prostate Cancer | Last Active: 5 hours ago | Replies (60)Comment receiving replies
My head is spinning! At a center of excellence along with 40 IMRTs I was prescribed 24 months of ADT (Orgovyx, Zytiga, Prednisone) for stage N1 metastatic hormone sensitive prostate cancer. Due to the annoying side effects I asked my MO if I might change from Zytiga to Nubeqa and reduce these treatment time to 18 months. She advised me she'd rather me continue with the Zytiga and endure the full 24 months. I assume being high risk and the treatment working well makes sense not to mess with success. PSA has been <.05 for many months. I sure am looking forward to getting off the ADT. Opinions on whether her recommendation sounds like a logical one?
Replies to "My head is spinning! At a center of excellence along with 40 IMRTs I was prescribed..."
@swl1956
I was on Zytiga for 2 1/2 years. In that time, I was only undetectable one month. It gave me high blood pressure, Many hot flashes, And multiple Afib Events where I had to go to the emergency room and be Cardioverted (Shocked back into normal rhythm).
It did give me 2 1/2 years, however. I moved on to Nubeqa And I’ve been undetectable for 31 months. I have had 16 years with PC, And since I have BRCA2, it is very aggressive. Zytiga gave me 2 1/2 years of the 16.
What I’m getting at is that having prostate cancer become a chronic disease can depend on you being willing to use a drug that is difficult but allows you to live longer so you can see more drugs come out that can give you an even longer future.
You can take Nubeqa As your next drug, If you need it.
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@swl1956 I cannot speak to the treatment plan you are on, other than to suggest a few things that are usually considered whenever embarking on ADT. Have you had a baseline bone density scan done? If not you should request that it be done. I did and found that I had osteoporosis . 24 months will impact your bone health so supplementing with calcium and vitamin d is generally used. Also if trying to maintain or preserve your sexual health, a penile pump and daily dosing of 5mg viagra is often used. I exercise strenuously twice a week for nearly 2 hours. The goal is to preserve muscle mass. On YouTube look for videos by Doctor John Mulhall, a sexual health urologist at Sloan Kettering.