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Forteo (teriparatide) followed by HRT: My Experience
Osteoporosis & Bone Health | Last Active: 8 hours ago | Replies (268)Comment receiving replies
@singingbones
From what I recall, you've already been on systemic estrogen for a few months - would you be open to sharing your dosage and form? Having that continuous transdermal or oral estrogen in place should help attenuate the expected CTX rebound after discontinuing Evenity. Monitoring your fasting CTX levels will give an early signal of whether your current HRT dose is sufficient to keep bone resorption suppressed.
As for my timeline, I checked baseline BTMs right at the completion of Forteo and before initiating HRT. then at 1, 3, and 6mo post-HRT, as I wanted to verify whether my low-dose (0.025 mg/day) estradiol patch was providing adequate antiresorptive protection. I am almost at the 2yr mark on HRT now and have a DXA scan scheduled in a few months - will report back.
Please keep us updated with your progress. Your experience with HRT as a follow-up for Evenity will be very valuable for others considering a similar path!
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@mayblin - after I sent this post I realize I had already shared w/you in the past--oops!
From https://melioguide.com/medications/evenity-a-physicians-perspective/
Apparently BTMs behave a bit differently for Evenity:
"EVENITY’s effect on bone turnover markers looks different from the other anabolic agents. With Forteo and Tymlos, both P1NP (a marker of bone formation) and CTX (a marker of bone resorption) rise. With EVENITY, P1NP rises while CTx decreases, reflecting its unique dual action: promoting bone formation while simultaneously reducing resorption, without directly stimulating either side of the remodeling cycle."
Yes, you are correct - I had my estradiol increased to address bone health less than 2 months ago & my last Evenity injection will be tomorrow - yay! I have been on a low dose of compounded vaginal estradiol/estrone for several yrs to address recurring UTIs - prescribed by a urologist! My integrative dr noticed the omission of progesterone & added that to my regime. The dosage was barely enough to register in any blood serum labs, so my very recent new dr modified the vaginal bi-est just a bit & then added 0.25 mg daily topical gel to address bone health systemically & kept the oral progesterone at 100 mg.
So, I won't have a clear delineation of before/after like you, but I am convinced HRT will be helpful - even at 73 yrs of age.
My osteo dr referred me to a Liftmor-type of exercise class given at a rehab medical facility here in CA, so I started that almost 8 mo ago. Like many on this forum, we've thrown everything we can at OP, so it's tricky to extract what has helped the most.
My current focus is on maintaining the gains that I suspect Evenity will have provided. I have a few other components I am considering, too, but much too long to include on this post. I stay active on Inspire.com and as far as I can tell, no one else has reported attempting to maintain gains without a prescription drug following Evenity. I'll keep you updated!