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Profile picture for jonyb @jonyb

Dear all,
I have a question for those with anti-MAG neuropathy or clinicians/researchers familiar with it.
I recently came across this post and it stated they have anti-MAG neuropathy associated with an IgG monoclonal MGUS rather than the usual IgM paraprotein. My wife's experts say she can't have anti-mag with an IgG M-spike but could they be wrong?
My understanding was that anti-MAG neuropathy is classically associated with an IgM monoclonal gammopathy,
Have any forum members been diagnosed with confirmed anti-MAG neuropathy in the presence of an IgG monoclonal protein rather than IgM?

If so:
Was the anti-MAG antibody level strongly positive?
Was the antibody shown to be IgG rather than IgM?
Were nerve conduction studies consistent with classical anti-MAG neuropathy?
Was another cause for the neuropathy considered?
I would be very interested in any published papers, case reports, or personal experiences, as I am trying to understand whether true anti-MAG neuropathy can occur with an IgG paraprotein or whether these cases usually turn out to be something different.
Many thanks
Jon

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Replies to "Dear all, I have a question for those with anti-MAG neuropathy or clinicians/researchers familiar with it...."

@jonyb interesting questions. My neurologist notes on his visit summary that my neuropathy is “likely” caused by MGUS, but my Hematologist/oncologist charts, “pt suffers from peripheral neuropathy” but he does not attribute this to MGUS.
I found this interesting.
https://ashpublications.org/hematology/article/2024/1/499/526243/Neurological-manifestations-of-MGUS
I’m hoping others will offer some inside.

@jonyb my oncologist and neurologist both have confirmed that you can have Anti-MAG with an IGg paraprotein. It is extremely rare. I would like to post to you my bloodwork and tests as any help and thoughts would be deeply appreciated.