Before Brinsupri I was on daily Azithromycin. Usually Levofloxacin and Z pack for flare ups. The Brinsupri and Colistimethate seems to work well. I also nebulizer 2X a day and use a flutter valve. I also exercise twice a week at Pulmonary Rehab. Mucinex and NAC to thin out mucus. A netty bottle to help with nasal mucus.