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Why Us?

Prostate Cancer | Last Active: 1 day ago | Replies (80)

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Profile picture for rlpostrp @rlpostrp

Yes indeed...irony...complete irony. I had a separate Genetic Screening at my local large medical center before I got my Decipher test results. The Genetic Screening told me that I had "zero" cancer genes, yet my Decipher Score was 50%. When I called to speak to Veracyte Labs in San Diego that does the Decipher test, I asked "what genes did they identify me as having?" They said they don't have identifiable genes to report...that the test is performed differently than I would expect. The PhD said that they couldn't help me with more specific information. There was no attitude or resistance...no desire to keep anything from me...she just explained that the way we all think the Decipher test is done, does not reveal identifiable genes that we have. So...THAT left me hugely confused. I asked Siri, and this is what I got for an answer:
"The Decipher Test focuses on genomic "classifiers" rather than specific gene mutations.
The Decipher Test is designed to assess the risk of prostate cancer progression by analyzing "gene expression patterns" rather than identifying specific genetic mutations." Here are some key points regarding its approach:

Genomic Classifier vs. Specific Genes
The test evaluates a 22-gene expression profile to generate a score that predicts "cancer behavior", rather than pinpointing individual gene mutations
.
This score helps in risk stratification and treatment decisions but does not provide detailed information about specific genetic alterations
.
Clinical Utility
The focus on gene expression allows for a broader understanding of tumor biology, which can be more relevant for treatment planning
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While it does not report specific mutations, it can guide therapy decisions based on the overall risk assessment
.
Limitations
The test does not incorporate traditional factors like PSA levels or Gleason scores into its scoring system, which can lead to some confusion
.
It is important to consider additional genetic testing if specific mutations are of interest, especially for targeted therapies."

Well...is everyone thoroughly confused now?

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Replies to "Yes indeed...irony...complete irony. I had a separate Genetic Screening at my local large medical center before..."

@rlpostrp Makes me glad I never had one! I just went with my own ‘gut’ feeling: hope for the best, plan for the worst and whatever happens, you’ve done your best.
Phil