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I am a 67-year-old female diagnosed with anti-MAG with a IgG MGUS and Cryoglobulinemia.
Symptoms have been ramping up as of late.
Over 6 years ago, they (UCSF) questioned whether or not I had MS. Then because of a monoclonal band and slowly increasing monoclonal serum protein count, it was a possibility of multiple myeloma. Last year in October my then oncologist had be tested for Anti-MAG and I tested positive. I also tested positive in 2024 for Cryoglobulinemia. My peripheral neuropathy is pretty hefty numb all the way from my toes up to my knees. My face goes numb and because both the anti-mag and the Cryoglobulinemia my body does not do well obviously in cold or heat. The two diseases exacerbate each other. My fatigue is hefty. The last bone marrow biopsy was negative and UCSF wants me to go back in July and do another bone marrow biopsy to see if there is and abnormal protein or B cells.

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Replies to "I am a 67-year-old female diagnosed with anti-MAG with a IgG MGUS and Cryoglobulinemia. Symptoms have..."

@lanijean11 first of all welcome to Mayo clinics connect. I hope that you will find, as I have, a community of support here. Although it’s unlikely that I will find someone with just the same symptoms and just the same lab results, imaging findings, and diagnoses, we have many commonalities.
I was diagnosed with MGUS in 2021. I have been fortunate in that my numbers have remained in the MGUS range and I have not progressed to smoldering or multiple myeloma. Because the risk of progression is very low, I hope to maintain my MGUS status indefinitely.
I have peripheral neuropathy in my feet. So far it has caused problems with balance and pain, but it has been otherwise fairly benign.
I am not familiar with Cryoglobulinemia nor with Anti-mag. Although they “watch and wait” with MGUS, do they offer treatment for either condition?
Hugs.
Patty