@hopeful33250 My husband takes sinemet at 7A, 11A, 3P and 7P. He has taken three does of Inbrija and says he has seen minimal to no improvement in his major 'off' symptom of extreme hot/cold body temps which really shut him down. Anyone else have this extreme temperature dysfunction? Face and groin sweating profusely and hands and feet and torso so cold he feels he's freezing. Hands feel as if they've been in ice water and forehead is red and sweating hot