Hi, @dewz13 You pose an interesting question! “Does anyone know if we can still donate organs with ET/Jak2?”
After reading several articles I’ve gathered that the risk of transmitting the JAK2 V617F mutation through organ donation is considered low, particularly if the donor has a well-controlled condition. However, the mutation can be present in the blood and may affect the recipient's health, especially if the recipient is already at risk for blood disorders.

There are several clinical papers discussing liver transplants with patient who receive livers from donors with ET -JAK2 V617F mutation.
One such paper is of a woman who had Essential thrombocythemia who passed away and could potentially be an organ donor. The recipient of her liver was a 68-year-old male with a history of end-stage liver cirrhosis secondary to alcohol consumption. He was given all the facts regarding the possibility of acquiring ET if they went ahead with the transplant. The doctors felt they could treat this condtion post transplant, if necessary. The patient was willing to accept the risks.

The transplant was a success, the JAK2 Mutated genes did show up in the patient’s blood test the day after transplant. But dissipated with subsequent blood work.
This led the doctors on the case to report, “We believe that it is reasonable for organ procurement organizations to offer organs from donors with JAK2 V617F mutations for transplantation into informed willing recipients within programs that provide appropriate follow-up, and in particular in situations in which the benefit from the transplant may supersede the potential and theoretical risk of MPN transmission.”
Here’s a link to that particular article from Hepatobiliary Surgery and Nutrition: https://hbsn.amegroups.org/article/view/23618/html

There are also research papers wondering:
Is it time to revisit contraindications to organ donation from donors with a JAK-2 mutation?
https://pubmed.ncbi.nlm.nih.gov/25778631/
Whether this is accepted across the board that’s hard to say. Not being a medical profession but just talking off the top of my head, I think with the demand on organs being high and availability low, that the transplant team would assess the potential side effects of going ahead with the donation if someone has a mutation with the JAK2 gene.
I think a reasonable team would weigh the long term success of the transplant against the risks before offering to the patient receiving the organ.

In my Allogenic bone marrow transplant, I received the stem cell donation from a donor. I was informed that my donor carried a latent virus in his system which I did not have. But that after the transplant I would most likely carry this virus as well. And I do! But my immune system is strong enough to prevent the virus from resurfacing. This donor was my 1 in 22,000,000 chance for life! I wasn’t going to toss that away for the potential of carrying a latent virus.
It think sometimes when it’s a choice between life and death, our ‘2nd hand’ organs or cells may come with a little baggage. But if the baggage can be safely ‘stowed’ away then I’m expecting the organs may be used. I know that I cannot donate organs because I carry 2 sets of DNA and that would be unpredictable for a recipient.

Bottom line, it would be best to consult with a healthcare professional or transplant center for personalized guidance regarding organ donation eligibility based on specific health conditions! How’s that? ☺️
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