I have been diagnosed with osteoporosis since 2003 and have been on alendronate twice or three times for five years at a time since my diagnosis (went on drug holidays in between). I am 73 years old. Last June-July, when I was on a drug holiday, my doctor prescribed Tymlos. I had very terrible side effects and had to stop after less than four months, last October. But one thing that did happen was a resorption of the root of one of my teeth. I did not link it with Tymlos, but reading some of the comments here, I wonder if this was caused by Tymlos? My dentist had done a full mouth x-ray about a year before my taking Tymlos and the resorption was not there. In a short period of time, it progressed so fast that while I would have wanted a root canal, I now have to have an extraction because the endodontist said he could not assure me that my tooth would be remain structurally stable for any length of time because of the resorption. Seven months after I stopped being on Tymlos my endocrinologist ordered blood tests and 24-hour urine calcium test to my measure my calcium, vit D, resorption ability, kidney function, etc. All of my results (calcium, vit d, parathyroid, CTX, eGFR, creatinine, etc) came back normal. I hope this means I won't have any more resorption. I plan to stay away from osteo meds from now on (esp Tymlos), and since January, have been improving my diet, taking protein shakes, AlgaeCal Plus, magnesium glycinate, and have enrolled in Onero. Although my DEXA scan confirmed severe osteoporosis after I stopped Tymlos, my REM scan showed very strong bones. The fact that I have (fortunately) not suffered any fractures probably confirms the validity of my REM scan.