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Anyone on Rybrevant (amivantamab-vmjw) for advanced NSC lung cancer?
Lung Cancer | Last Active: Jun 23 12:53pm | Replies (15)Comment receiving replies
@mamajite
I have the exon 21 L858R mutation. I poked around a little bit about it versus T790M but the landscape is littered with rabbit holes and I haven't absorbed enough to be articulate. Treatments for both are similar. I too had 20 or so nodules.
I thank you for your question. I also poked around a bit about multifocal; Mayo has done a lot of work with multifocal and some of it sounds encouraging. Maybe I should get treatment again. (I have appointments next week with both my local and my consulting oncologists.)
Which of course brings us back to the quality of life issues. I recently came across the following quote: “Manageable toxicity is not a label — it is an oxymoron.” Good luck to us all!
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@lijda the way I understand it, my inherited T790M mutation makes it easy to develop lung cancer, but it still requires an activating co-mutation. Patients like me tend to have a lot of nodules, so I was curious if you might have a similar diagnosis. I have/had 3 known primary tumors, one of which has L858R and it responded well to Tagrisso. Most people acquire the T790M mutation as resistance to first line treatment, so their situation is a bit different than mine. Today is actually my first day of a treatment pause after 2.5 years on Tagrisso - so your quote is apt!