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← Return to CTX and P1NP before 2nd shot
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@pdl57 All pure anti-resorption treatments, which denosumab (brand name Prolia) is one of, lower bone turnover markers. Even though the direct action that they take is to reduce bone breakdown, that causes bone-building to slow. Bone building is triggered, at least in part, by the osteoclasts finishing their job. So anything that only lowers bone breakdown has the unwanted effect of also lowering bone building. *
Reference: Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis
https://www.nejm.org/doi/full/10.1056/NEJMoa0809493
EXCERPT: "Denosumab ... blocks ... the development and activity of osteoclasts, decreasing bone resorption ... "
* Note that romosozumab (brand name Evenity) is the only OP drug that has both an anabolic bone-building action and it also inhibits bone breakdown. HRT is a less clear to me, but I believe it primarily reduces break-down but can sometimes stimulate bone building.
Romosozumab
https://www.ncbi.nlm.nih.gov/books/NBK585139/
EXCERPT: "Romosozumab ... This anabolic medication stimulates bone formation while suppressing bone resorption. "
Replies to "@pdl57 All pure anti-resorption treatments, which denosumab (brand name Prolia) is one of, lower bone turnover..."
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@kfhoz interestingly, when I was tested 3 months after starting Evenity, which is when it is in it’s anabolic phase, my P1NP dropped from 39 to 17. I would have understood if it was later in the 12 month cycle but we were just in the beginning portion.
As far as Prolia goes….I thought the ‘rule’ was they still wanted it to be about 100 before the next injection. I guess I will find out tomorrow before I get my 2nd injection.