Hi, I had 18 shots of Prolia, fro which I am relaying off mid July with Zolandronic Acid infusion.

I remember the GP testing me for the usual panels just before the second shot, and he added P1NP ( unfortunately the labels for CTX in the UK can not be precribed but the hospital).

However I remember perfectly well that it was suppressed down to 11, even if it was 4 weeks before the next injection.
I was then tested on 2 more occasions under Prolia and it was always suppressed to below the lowest normal range staying at around 11, even 7 !!! once.
The peculiarity of this drug is that it suppresses both bone resorbsion and new bone formation.
It is the only drug to have this effect on bone metabolism.
For this reason, although I will be monitored every 3 months with CTX and P1NP + on 3 monthly review protocol on regular basis for while for stopping the med, I am still very worried about out the rebound ang rhe risk of spontaneuos V. fractures.
I am expecting CTX to accelerate quickly above 350, while P1NP will be on a slower recovery.
Overall my gains were not great, I think.
Currently -2.3 lumber , -2.5 FN. Should have not been on it of this long, but unfortunately the rheumo wanted me to stay for life, and I don't want to be on it in my laten70s.
My health has suffered too much under this drug, so no more. Another pneumonia or another cellulites or another tooth exrraxtion jnder this medication is a problem for me since my immune system has weakend, and I have become more antibiotic resistant it seems.
I am 68, started in Prolia in 2014 at 56, with 3 yrs of ZA infusions in 2016, only to be put back on Prolia again end of 2018 which I regret.