ADT, it seems, is a necessary evil. Stage 4, Gleason 9, at age 73, I started with degarelix injections every month along with oral abiraterone w/ prednisone, then had IMRT with SBRT to a mets spot on RT iliac. After two years and a switch of physicians, I had two 90-day Eligard (Lupron) injections. Then I said, "Enough!" That was one year ago and symptoms aren't much different today, other than fewer hot flashes (but not gone). Lack of stamina is the big thing, loss of muscle, muscle aches and pains especially in my glutes and hamstrings and peripheral neuropathy with some numbness in lower legs and feet. My anemia remains - hemoglobin was 13.2 when I started ADT; it dropped to a low of 8.4 and is on a very slow incline ... up to 11.5. Testosterone is almost the same ... it started at 433, dropped to 3, and has risen to 23. But, PSA remains undetectable. I'm grateful I live in a time when they are getting so much better at treating this scourge and prolonging one's life. But it doesn't mean I'm liking the side effects of the treatment even after being off the stuff for a year.