Connect
← Return to Anyone diagnosed with Essential Thrombocythemia (ET) with CALR?
Discussion
Anyone diagnosed with Essential Thrombocythemia (ET) with CALR?
Blood Cancers & Disorders | Last Active: Apr 28 4:48am | Replies (37)Comment receiving replies
Hello everyone who has Et with clue mutations? Plus Anton have the kras mutation added?
Replies to "Hello everyone who has Et with clue mutations? Plus Anton have the kras mutation added?"
Hi,
I have CALR1. Sorry, I do not know what KRAS mutation is.
Yes, I have the CALR Exon 9 mutation.
Welcome Mayo Connect, @ally6lucas1 You popped into the right support group for members who have ET (essential thrombocythemia). This is a blood condition where there is slight change in a gene, in your case the CALR gene. This defect then allows for the over production of platelets.
It looks like your blood tests for possible mutations also discovered another genetic mutation referred to as KRAS. This mutation is a change in the KRAS gene that locks a key growth-signaling protein in the “on” position, causing cells to multiply uncontrollably. From my understanding it’s an acquired genetic mutation more often associated with cancers which may involve tumors more so than a blood condition.
Were both of these a recent discovery for you? Have you started any treatment for your ET?
Connect
I have CALR. Don't know what KRAS is except that it is sometimes associated with other types of cancers. I know researchers are trying to refine the mutation profile for us. Did yr doc tell you more about it these mutations?