Hello there, I started Besremi in July 2025. It has been very effective for me. My platelets went from over 1 million to 233. I am currently at at dose of 150 (down from 200) and have had only minor side effects - mostly dry mouth, some fatigue,some mouth sores, but those improved with a lower 150 dosage. I also had to increase my thyroid medication and my A1C went up. I wish you good health and that Besremi is effective for you.