Yes I started Besremi less than a year ago. I had been taking Hydroxy urea since 2021 when my platelets were 1400. My platelets were at about 900 when I started Besremi 6/25. now about 388. I had to go up to dose of 400 before it had any impact. I had severe brain fog at that dose but the platelets dropped and we dropped the dose. I’m now at a dose of 200 and feel good. Sometimes trouble sleeping.