Hi @lrs1953 There are a number of members who have Essential thrombocythemia who are taking Besremi to help lower their platelet levels. Here is a link to search results so you can take a look at the different conversations: https://connect.mayoclinic.org/search/

Hopefully the Besremi will do the job for you without having any more issues with neuropathy. Have your neuropathy symptoms improved since stopping the Hydroxyurea?