Decipher measures number of mutations in RNA segments - some mutations have nothing to do with PC so there is no need to check for ALL of the mutations.

Decipher measures number of mutations in the sample, "load" if you will. The more "scrambled" RNA is the higher the score.

Decipher will tell how aggressive the cancer is (or the potential of it becoming aggressive in the future) so if somebody is intermediate but has high Decipher it will change the course of the treatment. For example if somebody is 4+3 and low D., that person can avoid ADT, and if somebody is 4+3 and D. is 85, than ADT would be advisable. Same way Gleason 8 with low Decipher can avoid ADT , etc.

@fiskadoro for example has cancer that escaped his gland - it is in lymph nodes and vesicles ! Decipher would definitely help with treatment plan but as far as I know there would be very little chance that he can escape ADT since cancer is spreading : (((. I do not know why they did not suggest very early salvage ( before 0.1 ) with such case where cancer already escaped gland ?

Salvage RT has the best results when it is done before PSA reaches 0.2 , after that success is lower and lower. After 0.5 it is less effective.
https://link.springer.com/article/10.1007/s00345-025-05840-w