@taco Hi Taco. I had a full liver transplant two years ago. After 2 months in AZ Mayo sent us back home to CO. And while I have had issues (still have stenosis, CMV, blood clots, etc.) My only reaction to TAC was headaches at first and gut issues still. But Mayo has reduced my dosage of TAC a number of times over the last two years. While I have been careful always and do the right things I have only been sick with stuff I caught two times in two years. I now go to the stores , grocery shopping, ball games, we have even hosted a party with 30 friends and family at our house. No issues. I get out of the house every day. They have steadily reduced my TAC from 4 mg per day ( 2 am, 2 pm) to now 1 a day (.5 am, .5 pm). Best of luck.