@jodyjazz I did a bunch of research on the HU. Found this discussion thread. Found a MPN specialist, or rather bonemarrow diseases specialist, after my HEMO said to just take HU, and aspirin, like no big deal, HU after all is "generally well-tolerated"!. Well, that was a bit of a shocker for me, as I , like many on here, was not on any medicines, take quite good care of myself, and did not even have aspirin or tylenol in the house. As a result of now seeing the bone marrow specialist, I have been on 'just' aspirin, and we are watching my platelets via bloodtests every 3 mos. They have been 'stable' around 480 for the past year and half. So, I have saved myself that time of not being on HU.