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Effectiveness of HU on ET w/MPL?

Blood Cancers & Disorders | Last Active: May 31 9:27am | Replies (33)

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Profile picture for krag1949 @krag1949

before starting HU WBC was 32.4. Platelet count was 852, my journey started in July of 2025 when it was supposed I had infection from hardware following reconstructive foot surgery in July of 2024. After infusions of antibiotics it was noted WBC went sky high, antibiotics not helping. Referred to Hemo /oncologist. Diagnosed with essential or reactive T. Looking at Hemo notes the word ambiguous was used which makes me wonder if all of this is still coming from the foot, which right now needs ankle replacement surgery. Who knows????

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Replies to "before starting HU WBC was 32.4. Platelet count was 852, my journey started in July of..."

@krag1949

REACTIVE ET, in response to trauma such as surgery, is certainly possible. I don't know how long reactive ET persists.

ESSENTIAL ET means one of the three proteins regulating blood production has gone wonky (unless you're TRIPLE NEGATIVE, the biggest mystery of all). Essential ET's a lifelong condition.

Do you know, has an abnormal driver (JAK, CAL or MPL) ever been found in your blood work?