← Return to ADT or no ADT? What should I ask my Oncolgist?

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ADT or no ADT? What should I ask my Oncolgist?

Prostate Cancer | Last Active: May 28 7:09pm | Replies (50)
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Profile picture for surftohealth88 @surftohealth88

@climateguy
Some studies show that the most loss actually happen in "acute" stage of ADT treatment (initiation of ADT) :
"Men on acute ADT had a similar rate of bone loss to men on chronic ADT. Reversibility in ADT-induced bone loss was observed in those who discontinued ADT. Serum levels of PINP and CTX were higher in acute and chronic ADT users and levels returned to the range of PCa controls when treatment was withdrawn."

I think that it is wise to do all that one can do to prevent bone loss as soon as ADT starts.

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Replies to "@climateguy Some studies show that the most loss actually happen in "acute" stage of ADT treatment..."
climateguy | @climateguy | May 26 9:32pm

@surftohealth88 Thanks for drawing my attention to that. Obviously my complacency about "only" 6 months of ADT having little effect on my bone mineral density appears to be an ignorant assumption.

I presume the study you quote from is "Effect of Androgen Deprivation Therapy on Bone Mineral Density in a Prostate Cancer Cohort in New Zealand: A Pilot Study" https://pmc.ncbi.nlm.nih.gov/articles/PMC5638161/

I think a guy like Newton would call the bone mineral density loss rates measured in that study "catastrophic".

I'll be studying this topic with a lot more intensity in the next few weeks.

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