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Anyone take Anastrozole every other day?

Posted by kamra @kamra, Dec 5, 2024

I wonder if anyone here takes Anastrozole every other day. If so, does it lessen your side effects? Thank you.

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myoga | @myoga | May 4 5:09pm
In reply to @myoga "@brightlight66 Thanks! I would like to give you two thumbs up but we don’t have that..." + (show)
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@brightlight66
Thanks! I would like to give you two thumbs up but we don’t have that option.

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@myoga
I also found this when I was taking Letrozole. I planned to take a month off after a year of taking Letrozole but never made it to one year. There are strong chance that eventually the cancer will develop resistance to AI. Should we take a break once in a while to prevent the resistance?
https://pmc.ncbi.nlm.nih.gov/articles/PMC2491346/

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jwmusic65 | @jwmusic65 | 1 day ago
In reply to @saraabrooks "I'm surprised they're so adamant about not every other day. Considering that this one dose has..." + (show)
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I'm surprised they're so adamant about not every other day. Considering that this one dose has a 50-hour half life. So you're doubling and tripling up every time you take a pill? Is that why you get sick later rather than at first. I am so tired I can't lift my head off the pillow. I sleep 24/7 almost. I have no energy to walk one small block to the pharmacy. I feel sick all the time. I swear to God this is not living. I do not even want to stay alive like this.

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@saraabrooks I am struggling with this medication, too. It just adds to the stress of the whole situation. I’m taking a week away from it and going to restart at a pace that works fir me. At age 80 … I feel a lot of this is “my choice”!

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@mimi09 | @mimi09 | 9 hours ago

If I’ve written this in the past, so sorry to repeat myself! In the “old days” radiation dosage for breast cancer was much higher than it is with today’s treatments. And with experience, testing, and studies, the dosage was reduced. Great for some of us…not for some others. Ditto dosages in early birth control pills!
Perhaps the same is true for our current oral meds: dosages too high with so many side effects that are impossible to tolerate. Perhaps a half-dose, or even a quarter-dose would be sufficient.

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jmab | @jmab | 5 hours ago
In reply to @mimi09 "If I’ve written this in the past, so sorry to repeat myself! In the “old days”..." + (show)
Profile picture for @mimi09 @mimi09

If I’ve written this in the past, so sorry to repeat myself! In the “old days” radiation dosage for breast cancer was much higher than it is with today’s treatments. And with experience, testing, and studies, the dosage was reduced. Great for some of us…not for some others. Ditto dosages in early birth control pills!
Perhaps the same is true for our current oral meds: dosages too high with so many side effects that are impossible to tolerate. Perhaps a half-dose, or even a quarter-dose would be sufficient.

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@mimi09 the standard dose of Tamoxifen used to be 40 mg, now it's 20 mg. And current, on-going clinical trials suggest that 10 mg & even 5 mg have benefits. Will be interesting to see final results from these trials! (I have always taken 10 mg Tamoxifen.)

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