I had all the same kinks as your husband after Whipple and my surgeon said no to Creon, too. However, her PA prescribed it, saying it was worth a try. My gastroenterologist also said we could give it a try, but did not seem eager to prescribe it. I haven’t gotten a clear answer about taking Creon, so may depend on how each person reacts to Whipple. I don’t know if there is a way to check which digestive enzymes are deficient after Whipple.