I was just diagnosed with ET JAK2 this past March. Taking Hydroxyurea 500 mg twice daily and baby aspirin. My platelet count is slowly coming down from a high of 1027 in February to 684 in early May. I had a bad reaction when I had an Zoledronic Acid infusion for osteoporosis 4 days after starting Hydroxyurea - severe headache, vomiting and diarrhea. The body said too much new stuff at one time.