@msfauber Two years ago, I felt exactly the same. I had reacted badly to every statin tried, but my total cholesterol and LDL continued to climb, then I was diagnosed with coronary artery disease - time for something.

Fast forward 2 years, my numbers are great, and my side effects are very mild and predictable. The day after my injection, I have a little fatigue, so I try not to schedule too much. I found it works best to take it a bedtime. And every couple months, I have a day or so of nasal congestion, but now I understand I'm not "coming down with something."

Remember, sometimes when we read on-line forums like Mayo Connect, we are usually only hearing from those who had a reaction, side effect or failed surgery. The thousands or millions without any isse are just out there living their lives.

@msfauber I've been on Repatha more than 2 years. Shortly after taking it I had a runny nose for about a month; never sure was that from Repatha or just normal living. Since then, zero side effects other than a dramatic reduction in total C and LDL. Had my latest dose this morning.

Good luck in your journey