I was just diagnosed the beginning of March this year. JAK2 positive, platelet count was 1027. Apparently it had been rising for at minimum the past 3 years, but no one in my PCP's office noticed the abnormal lab results sent to them when I had hip and knee replacement surgeries during that time period. I am taking 500mg of Hydroxyurea twice daily every day. Had a bad reaction one week in, a couple days after having an infusion for my osteoporosis. Not sure how we'll handle that next March when I get my next infusion. Anyone else have experience with that? My infusion is Zoledronic Acid, 1mg. I have great confidence in my young oncologist. He is referring me to another clinic, Fred Hutchinson Cancer Center in Seattle, for a second opinion. Kind of has a leave no stone unturned approach about him. My spleen is fine, but 30% of my bone marrow has fibrosis grade 2, 70% is grade 1. I keep telling myself and family/friends that if you have to have a cancer, this one doesn't seem too bad. I have noticed that in the 2 months since my bone marrow biopsy that the site seems a bit tender, has a dull steady ache to it deep down. Anyone else experience this? I'm grateful I stumbled on this site last week.