@geneva26 What was the BCR prediction from Prolaris? There is about 2/3s agreement between the two tests but Decipher is slightly superior in predicting BCR. The real question is what would you do differently based on the results of these tests? Are you thinking about staying on Orgovyx for another year? Since you have already had radiation treatment there is not much to decide except the frequency of PSA tests with every 3 months for the first 2 years being typical. It is not unusual to see a bounce after ADT ends but it should continue to trend down after that. BCR after radiation is defined as a PSA increase of 2, but you should probably start checking if it increases to 1. Until it reaches these levels there is no other action like MRIs or biopsy which could happen on active surveillance pre-treatment. If you have a BCR a PSMA PET scan will be ordered to determine the PSA source.