@surftohealth88 I had RP surgery 11/11/24 and my Gleason also went from 4+3 to 4+5. PSA was at 0.02 after 8 months, and 0.04 after 11 months. Even though it was still low we decided to move ahead with radiation because it was trending the wrong direction. I had a single Lupron shot in October 2-25 and 39 radiation sessions from 12/8/25 to 2/4/26. As of 2/18 my PSA was <0.01. My only side effects were fatigue from the radiation and hot flashes from the Lupron. I'm getting my energy back but the hot flashes continue. I'm feeling good about the process so far. My next appointment with radiation oncology is in early July.