@altabiznet there are numerous articles that can be accessed through google scholar. I only read the highlights and then it got to be too confusing for me. The following 2 articles are a sample.
https://academic.oup.com/mr/article-abstract/33/6/1068/7117735
https://www.sciencedirect.com/science/article/abs/pii/S1567576920301648
One article highlighted a chemotherapy drug for use on SSc, but it is a very toxic drug and you really don’t want it. I had about 8 cycles of it and ended up in the ER after the 1st one.