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Hormone Therapy (ADT) when ArteraAI Test says it's not necessary
Prostate Cancer | Last Active: May 19 8:50am | Replies (47)Comment receiving replies
@jeffmarc OK, that’s interesting…but I think in your case the BRCA mutation pretty much makes your cancer aggressive which then leads to castrate resistance; I’ve read some studies - I’m sure you have read them all - where men are first tested for BRCA only because ADT stopped working; once they were found to have the mutation they were placed on PARP inhibitors.
Are you on one?
I think you were on Zytiga or Nubeqa but those aren’t PARP inhibitors. Thanks!
Phil
Replies to "@jeffmarc OK, that’s interesting…but I think in your case the BRCA mutation pretty much makes your..."
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@heavyphil
When I became castrate resistant to ADT, they did not know I had BRCA2. so I was put on Casodex for 15 months and then Zytiga. After 2 1/2 years, I switched to Nubeqa. I did take a PARP inhibitor for about five days, Then I spoke to my oncologist and said, This doesn’t make sense why aren’t I on Nubeqa, And she agreed to put me on it. Since it is work so well, there’s no need for me to be on a PARP until after it fails.
I found out I was BRCA2 in March 2022 while I was on Zytiga.
The side effects of the PARP are pretty serious so I really would like to avoid it as long as possible.