my dr who is MPN specialist kept telling me that ET does not cause bone pain, but I had bone pain before I was diagnosed and had rising platelets. I've been to MPN conference where they do acknowledge bone pain from MPNs, My dr also kept telling me take tylenol which doesn't help (for me), I finally asked to see pain mgmt dr, and they acknowledged that tylenol doesn't work for everyone, so I got tramadol, which does work.