Connect
← Return to Hormone Therapy (ADT) when ArteraAI Test says it's not necessary
Discussion
Hormone Therapy (ADT) when ArteraAI Test says it's not necessary
Prostate Cancer | Last Active: May 19 8:50am | Replies (47)Comment receiving replies
@pesquallie A bit misleading…5% of WHAT men? What Gleason score, category, Decipher, etc?
There are way more than 5% of men living with metastatic PCa that are only still alive because of ADT.
Yes, there are SE’s but not all men suffer from them and some react much less than others. AI still only ‘knows’ what WE know - it’s more like a Vegas odds-maker at this point, giving its best opinion on hundreds of studies that have already been done. It still cannot ‘think’ for itself.
Phil
Replies to "@pesquallie A bit misleading…5% of WHAT men? What Gleason score, category, Decipher, etc? There are way..."
@heavyphil
On the question of "who benefits from ADT and is it worth the side effects"? I just had an appointment with my RO at Johns Hopkins where he considered whether to add ADT to SRT. (Short story: I had RALP in 9/25; PSA still low but rising; aggressive cancer (IDC, Cribriform, EPE, Decipher .89, but clean margins on pre-surgery PET). The determining factor for him to add ADT was the detailed report that accompanied the Decipher one page summary. It showed I had Luminal B, an aggressive subgroup. The trial (which has not yet been peer reviewed) NRG GU006 (BALANCE) showed a clear benefit of adding apalutamide to SRT. If you have a high Decipher score, ask your doctor to get the detailed report that accompanies the one page summary. You can also google "NRG GU006 (BALANCE) and Luminal B" to see a discussion of the study.
Connect
@heavyphil
The Duke report indicates that aggressive prostate cancer responds best to high testosterone levels which is in sharp contrast to old methods.